دانلود کتاب Vitamin D. Basic Research and its Clinical Application: Proceedings of the Fourth Workshop on Vitamin D, Berlin, West Germany, February 1979

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Foreword\nContents\nChemistry, Structure, Function and Biological Assay\nIntroduction\nSynthesis of Some Side Chain Analogues of Vitamin D₃ Metabolites\nStructural Transformations on Vitamin D\nDistribution and Activity of a Vitamin D₃ Compound in Trisetum Flavescens\nSynthesis and Biological Activity of 24R-Hydroxy-25-fluorocholecalciferol and 1a, 24R-Dihydroxy-25-fluorocholecalciferol\nThe Synthesis and Biological Evaluation of Fluorinated Analoges as Probes of Vitamin Da Metabolism\n19-Substituted-10,19-Dihydrovitamins via Hydrozirconation of Vitamin D₃\nThe Synthesis of 1a, 3a-Dihydroxy-25Methylcholesta-5,7-Diene-24-OIC Acid, and of la, 3a-Dihydroxy-25 Methylcholesta-5,7-Diene\nInterconversion of Vitamin D and Trans-Vitamin D by Triplet-Sensitized Isomerization\nThe Use of UV, CD, ²H-NMR Spectroscopy and Mass Spectrometry for the Investigation of Conformational Mobility of Vitamin D and Previtamin D and their Interconversion\n25 (R), 26 and 25 (S), 26-(OH)₂D₃: Biological Activity in Intact and Nephrectomized Rats. Comparative Effects of 1, 25, 24 (R), 25-(OH)₂D₃ and I, 24 (R), 25-(OH)₃D₃\nInhibitors of Vitamin D Metabolism and Action\nC(1)-Hydroxylation of Vitamin D₃ and Related Compounds\nVitamin D₃ Sulfate in Lactating normally fed Rats and Suckling Pups After Maternal Administration of ³H Vitamin D₃ or ³⁵S Vitamin D3 Sulfate\nSynthesis of Vitamin D Analogues and their Covalent Binding to Affinity Chromatographic Media\nOsteoporosis\nCalcium Absorption and Plasma 1,25 (OH)₂D Levels in Post-Menopausal Osteoporosis\nOsteoporosis and Age-Related Osteopenia: Evaluation of Possible Role of Vitamin D Endocrine System in Pathogenesis of Intestinal Calcium Absorption\nTwo Years Experience of Oral Treatment with 1a-Hydroxyvitamin D and Calcium in Patients with Senile or Postmenopausal Osteoporosis\nThe Treatment of Osteoporosis with 24,25 Dihydroxycholecalciferol A Pilot Study\nOsteomalacic Factors in the Osteoporosis and the Treatment of Osteoporotic Patients with Vitamin D₂ and 1aOHD₃\nTranscalciferan/D-Binding Protein(s)\nBiologic Significance of Genetic Variation in Human Gc (Vitamin D-Binding Protein)\nThe Transport of Vitamin D\nStructure and Properties of Human Plasma Vitamin D Transport Protein (Group-Specific Component)\nSerum Vitamin D Binding and Gc Polymorphism\nSunlight, Skin and Seasonal Effects\nIdentification of in Vivo Generated Previtamin D₃, Vitamin D₃ and 25-Hydroxyvitamin D₃ in the Vitamin D-Deficient Rats Irradiated by Ultraviolet Light\nResponse of Plasma 250HD to Standardized Ultra Violet Radiation\nEffects of Sunlight Exposure on Blood Concentration of Vitamin D Derivatives in Healthy Japanese Adults\nContribution of Skin Vitamin D₃ Synthesis in Patients Receiving Total Parenteral Nutrition\nThe Photo-Biochemistry of Vitamin D₃ in Vivo in the Skin\nAssays for Vitamin D Metabolites\nMeasurement of Plasma 1,25 (OH)₂ Vitamin D by Protein Binding Assay and Radioimmunoassay\nUse of Isotope Dilution Mass Fragmentography in Vitamin D Research\nAssay of 1,25-Dihydroxyvitamin D and Other Active Vitamin D Metabolites in Serum: Application to Animals and Humans\n24,25-Dihydoxyvitamin D in Human Serum\nRadioimmunoassay of Vitamin D Metabolites\nAssays for Vitamin D and its Metabolites\nRadioimmunoassay for Circulating 1,25- and 25,26-Dihydroxycholecaliferols in Man\nHemisuccinates of Vitamin D₃ and of its Metabolites\nStudies on Antisera against Vitamin D Metabolites\nThe Measurement of Various Vitamin D Derivatives in Plasma Using High-Pressure Liquid Chromatography\nAssay of 1,25- and 24,25 Dihydoxycholecalciferol in Human Serum - some Technical Considerations\nRadiocompetitive Protein Binding Assays for 25-Hydroxy Vitamin D, 24,25-Dihydroxyvitamin D and 1,25-Dihydroxy-vitamin D in Human Serum\nSteroid Receptors: What do We not Know?\nVitamin D - Parathyroid Hormone\nCholecalcifediol suppression of PTH Secretion from Monolayer Culture of Human Parathyroid Carcinoma Cells\nThe Effect of Human Growth Hormone Replacement on Parathyroid Function and Vitamin D Metabolism\nSerum Calcium Concentration: Possible Regulator of Renal Parathyroid Hormone Action\nEffects of Vitamin D3 Metabolites Injection into Thyro-parathyroidectomized Pregnant Rats on Fetal Weight and Liver Glycogen Stores in Mothers and Fetuses\nEffects of Vitamin Deficiency on Calcium-Binding Proteins and on Plasma Calcitonin and Parathyroid Hormone Levels in Growing Pigs\n1,25 Dihydroxycholecalciferol effect on in Vitro Immunoreactive Human Parathyroid Hormone Secretion from Hyperplastic Glands\nQuantitative Changes of Rat Thyroid C Cell Population in Hyper- and Hypovitaminosis D\nThe Interactions Between Vitamin D Metabolites, Parathyroid Hormone and Calcitonin\nIn Vivo Suppression of Parathyroid Hormone Secretion by 24,25 Dihydroxy Cholecalciferol in Hyperparathyroid Dogs\nRenal Actions\nAcute and Chronic Effects of Vitamin D Metabolites on the Renal Handling of Phosphate\nInteraction of Vitamin D Metabolites with Parathyroid Hormone and Vasopressin\nPhosphaturie Effect of Parathyroid Hormone in Phosphate Depleted Man\nVitamin D in Maternal, Fetal and Neonatal Conditions\nLong Term Effects of Low 25-Hydroxyvitamin D (25-OHD) Serum Concentrations in Premature infants: A Preliminary Report\nVitamin D, Calcium and Phosphorus Requirements and Bone Mineralization in Preterm Infants\nThe Transplacental Movement of Metabolites of Vitamin D in the Sheep\nThe Effects of Solanum Glaucophyllum Ingestion by Pregnant Cows on Plasma Calcium Levels in Dams, Fetuses and Neonates and on the Mineral Composition of Colostrum\nThe Vitamin D₃ Requirement for Premature Infants\nCalcium Uptake and Binding by Membrane Fractions of Human Placenta: ATP Dependent Calcium Accumulation\nSkeletal Actions\nInfluence of 1,25(OH)₂D₃ on Bone Surface Lining Cells and on cartilage mineralisation in vitro. Ultrastructural studies\nThe Role of Vitamin D Metabolites in Calcification of Chicken Epiphysis\nBone Mineral Solubility and its Alteration by 1,25-Dihydroxyvitamin D₃\nAccelerated Bone Formation in End Stage Renal Disease\n24,25-Dihydroxyvitamin D: The Preferred Metabolite for Bone\nCellular Location and Regulation of the 24,25-Dihydroxyvitamin D₃ Formation in Cultured Cells from Bone and Cartilage\nComparison of the Histological Effect and Metabolism of 25-(OH)D and 1,25-(OH)₂D in Rat Bone\nAction of Solanum Malacoxylon on Bone Histology of Vitamin D Deficient Rats\nDual Action of Parathyroid Hormone on the Mineralization of Rat Incisor Dentin\nInfluence of Diet on the Response of Bone Cells to 1,25-OH)₂D₃ in Thyroparathyroidectomized Rats\nNuclear Binding of 24,25-(OH)₂D₃ and its Effect on DNA Polymerase Activities in Cultured Chondrocytes\nEffects and Interaction of 1,25 (OH)₂Ds and 24,25 (OH)₂D₃ on Bone\nEffects on Mineral Homeostasis of 1,25 (OH)₂D₃ and 24,25 (OH)₂D₃, Alone and in Combination, in Rats\nEffect of Dihydroxylated Vitamin D Metabolites on Experimental Rickets\nEvidence for the Presence of 25-OH-D₃ Binding Proteins in Embryonic Cartilage\nGlucocorticoid Dependence of Cytosol 1,25-Dihydroxycholecalciferol Receptors in Fetal Rat Calvaria\nVitamin D Metabolism\nRecent Developments in the Metabolism of Vitamin D\nThe Role of Systemic PH in the Bioactivation of Vitamin D\nThe Site of Synthesis of 1,25(OH)₂ Vitamin D₃ in the Kidney A Microenzymatic Assay on Isolated Tubules\nResponse of Chick Kidney Cell Cultures to 1,25-Dihydroxyvitamin D₃\nGrowth Hormone and Prolactin Action on Vitamin D Metabolism in the Rat\nEffective Liver 25-Hydroxylation of Vitamin D under Chronic Ethanol Administration in the Rat\nCalcium Transport by Rat Colon: Response to 1a,25(OH)₂D₃ and Dietary Calcium Restriction\nDirect Vitamin D3-Metabolite Regulation of Kidney 25-Hydroxyvitamin D₃ Metabolism\nThe Regulation of 25-Hydroxylation by Vitamin D Intake in Man: A Theoretical Model\nMinimal Deprivation of Vitamin D Enables Parathyroid Hormone to Stimulate 25-OH Vitamin D - 1a-Hydroxylase\nVitamin D Metabolism in Japanese Quail: Effects of Lead Exposure and Dietary Calcium\nEvidence for a Calcium-Dependent, PTH-lndependent Regulation of Plasma 1,25-Dihydroxyvitamin D in Rats\nComputer Modeling of Vitamin Metabolism\nProlactin, Growth Hormone and Vitamin D Metabolism\nA Study of the Physiologic Significance of 24-Hydroxylation of 25-Hydroxyvitamin D\nDynamic Aspects of Vitamin D Metabolism: Formation of Hydroxylated Metabolites from A Physiological Dose of Cholecalciferol in Vitamin D Depleted Man\nThe Regulation of Plasma 1,25-(OH)₂-D Concentrations in Healthy Adults\nThe Role of the Liver in the Control of Vitamin D Metabolism\nProstaglandins and 25-Hydroxyvitamin D-1a-Hydroxylase\nRegulation of Plasma Levels of 1,25 Dihydroxy Vitamin D in Growing Dogs with Thyroparathroidectomy and Varying Amounts of Parathyroid Hormone\nBoth 24R,25-Dihydroxyvitamin D₃ and 1a,25-Dihydroxyvitamin D₃ are Indispensable for Normal Calcium and Phosphorus Homeostasis\nNew Renal Metabolites of 24,25-Dihydroxyvitamin Ds in the Chick\nThe 1a- and 24-Hydroxylases of 25-Hydroxycholecalciferol: one or two Enzymes?\nRegulation of 25-Hydroxycholecalciferol-1 and -24-Hydroxylases in Cultured Kidney Cells\nPossible Extra-Renal 25-OHD₃-1a-Hydroxylase Activity in the Pregnant Rat\nThe Absorption and Metabolism of Vitamin D₃ from Parenteral Injection Sites\n1,25-(OH)₂ Vitamin D₃ & 24,25-(OH)₂ Vitamin D₃ Synthesis by the Isolated Perfused Rat Kidney\nIn Vitro Regulation of 25-Hydroxyvitamin D₃ Metabolism by Avian Kidney Cells in Serum-Free Medium\nComparative Studies on Mitochondrial and Microsomal NADPH-Cytochromec Reductases of Chick Tissues\nEffect of Pregnancy, Acromegaly, Primary Hyperparathyroidism and Prolactinoma on 1,25-Dihydroxyvitamin D in Man\nRelationship of Dietary Phosphorus Restriction to Calcium Absorption and Vitamin D Metabolism\nIntestinal Actions and Calcium Binding Protein: Meaning of Non-Parallel 1,25-Dihydroxycholecalciferol Mediated\nResponse Relationship in Intestine and Bone to Dose and Time\nCytoplasmic Localization of the Calcium Binding Protein in Rat Duodenal Absorptive Cells\nVisualization of Vitamin D-Dependent Calcium Binding Protein in Chick Intestine by Immuno-Scanning Electron Microscopy\nInfluence of High Doses of Vitamin D₃ on Broilers and Adult Hens\nPurification of the Intestinal Receptor for 1,25-Dihydroxyvitamin D\nRecent Progress on the Application of Affinity and Covalent Chromatography to the Purification of the 1,25-Dihydroxyvitamin D₃ Receptor from Chick Intestinal Mucosa\n1,25-Dihydroxycholecalciferol and the Prevention of Parturient Hypocalcemia and Paresis (\"Milk Fever\") in Pregnant Dairy Cows\nA Vitamin D-Induced, Calcium-Binding Protein from Rat Intestinal Brush Border\nRelationship of Intestinal Calcium Absorption to Intestinal and Plasma Calcium Binding Protein Measured by a Radioimmunoassay\nThe Effect of 1,25-Dihydroxycholecalciferol and Hydrocortisone on the Development of the Embryonic Chick Duodenum\nTheories on the Mechanism of Action of 1,25(OH)₃D₃ on Active Intestinal Calcium and Inorganic Phosphate Absorption: are the Calcium and Phosphate Transport Processes Coupled, Uncoupled or Both?\nFundamental Actions of 1,25 Dihydroxycholecalciferol on Intestinal Ion Transport do not Involve Gene Activation\nThe Effect of Cholecalciferol on the Phosphorylation of Intestinal Membrane Proteins\nSome Biochemical Responses of Chick Intestine to 1,25- Dihydroxyvitamin D\nInduction of Metallothionein(s) in Organ-Cultured Duodenum: Relationship to 1a,25-(OH)₂D₃-lnduced CaBP Synthesis\nVitamin D and Calcium Absorption: Computer Simulation\nRenal Osteodystrophy\nClinical Assessments of Vitamin D₃ - Therapy in Patients on Longterm Haemodialysis\nAdverse Effects of Vitamin D Metabolites on Osteitis Fibrosa in Patients on Chronic Hemodialysis: Critical Role of Induced Hyperphosphatemia\nAssessment of Long-Term Effects of 1a(OH)D₃ on PTH Secretion, Intestinal Calcium Absorption and Bone in Chronic Renal Failure\nHypergonadotropic Hypogonadism in Renal Failure - A Defect Responsive to 1,25(OH)₂D₃\nComparative Effects of 1,25-Dihydroxycholecalciferol and Cholecalciferol in non-Dialyzed Chronic Renal Failure\nMedium term Effects of 1,25-Dihydroxy-vitamin D in Patients with Renal Osteopathy\nThe Early Detection and Treatment of Renal Osteodystrophy\nThe Combined Use of Human Calcitonin and 1,25-Dihydroxycholecalciferol in the Treatment of Renal Osteodystrophy\nIntestinal Calcium Transport in Vitro as Influenced by Azotemia, Dietary Calcium, Parathyroidectomy and 1,25-Dihydroxycholecalciferol (1,25-DHCC) Treatment. - Role of Calcium - ATPase\nRecurrence of Hyperparathyroidism from Autografted Parathyroid Fragments in Uremic Patients in Spite of Administration of 25(OH)D₃ and 1a(OH)D₃\n25 Hydroxycholecalciferol Plasma Levels in Anephric Patients After Oral Loading of Vitamin D\nThe Histological Study on Experimental Renal Osteodystrophy in Rats\nLong Term Effects of Small Doses of 1,25 Dihydroxycholecalciferol in Dialysis Patients\nClinical and Biological Efficiency of 1,25 Dihydrocholecalciferol in Chronic Dialysis Patients with Renal Osteodystrophy\nHistomorphometric Evaluation of the effect of 1,25-DHCC in Type II and III of Renal Bone Disorders\nHistomorphometry of Bone Changes in Renal Osteodystrophy After Treatment with 1,25-Dihydroxycholecalciferol\nThe use of 5,6-trans-25-OH-Cholecalciferol in the Treatment of Patients with Fully Developed Renal Osteopathy Requiring Dialysis: Therapeutical Application and Treatment Results\nClinical Experience in Long Term Treatment with 1,25-DHCC in Different Histological Forms of Renal Osteopathy\nCalcium-Phosphorus Metabolism and Renal Function During 1a-OH-D₃ Vitamin Treatment of Patients with Chronic Renal Disease\nNewcastle Bone Disease\nThe Measurement of 1,25-(OH)₂-D by Competitive Protein Binding Assay in the Plasma of Anephric Patients: The Effects of Dihydrotachysterol Therapy\n25-Hydroxycholecalciferol and 1,25 Dihydroxycholecalciferol in the Treatment of Renal Osteodystrophy\nBone Histomorphometry in Children with Early Chronic Renal Failure Treated with 25 (OH)D₃\nHypercalcemia During Treatment of Uremic Patients with 1,25(OH)₂D₃: Analysis of 43 Cases\nRenal Bone Disorder in Children: Therapy with Vitamin D₃ or 1,25- Dihydroxycholecalciferol\nTreatment of Predialysis Renal Bone Disease with 1a-(OH) Vitamin D₃ and 1.25-(OH)₂ Vitamin D₃. Initial Results of Balance Studies and the Effect on Intestinal Calcium Absorption, Serum PTH and Calcitonin Levels\nThe Effect of 1-a-OHD₃ on Bone Changes in Non-Dialysed Patients with Chronic Renal Insufficiency\n25 Hydroxyvitamin D in Renal Osteodystrophy: Long Term Results of A Six-Center Trial\nFurther Therapeutical Experience with the Vitamin D Analog 5,6-trans-25-OHCC in Renal Osteopathy\nA New Laboratory Model for Renal Osteodystrophy and Vitamin D\nThe Influence of Uremia, Aluminiumhydroxide and Various Vitamin D Compounds on the Course of Nutritional Rickets in Rats\nEffect of Vitamin D Analogs in Rats with Experimental Renal Osteodystrophy\nEvaluation of Histological Procedures in the Investigation of Bone Disease Related to Vitamin D\nPathophysiology of Vitamin D Related Diseases\nEffects of in Vitro and in Vivo Sodium Restriction on Corticosteroidinduced Intestinal Calcium Malabsorption\nTrisetum Calcinosis: Current Status of Clinical Research\nX-Linked Hypophosphatemia is a Disorder of Phosphate Transport in the Renal Brush Border Membrane in the Hypophosphatemic Mouse. Why is Serum 1,25-(OH)₂D Low in the Human Homologue?\nThe Effect of Vitamin D₃ and Metabolites on Magnesium Metabolism\nSubnormal Serum 1,25-Dihydroxyvitamin D₃ Levels in Children with Glomerular Disease Receiving Corticosteroids\nRegulation of Serum Phosphorus by 1,25(OH)₂D₃\nUnexplained hypercalcemia:? Sarcoidosis sine Sarcoidosis: with Elevated Serum Level of 1,25 DHCC\nVitamin D Metabolites in Hypercalcitoninemic States\nTarget Cell Resistance in Pseudohypoparathyroidism: Single or Multiple?\nVitamin D Metabolism In Patients with Nephrolithiasis\nEvidence for Abnormal Metabolism of Vitamin D in Sarcoidosis\nEffects of Experimental Diabetes in the Rat on Calcium Transport and Vitamin D Metabolism\nAbsorption of Vitamin D and 25-OH Vitamin D in patients with Intestinal Malabsorption\nEffect of Diabetes in Rats on the Metabolism of Cholecalciferol and 25-Hydroxycholecalciferol\nDo Alkaline Phosphatases Have a Physiological Function?\nClinical Application of the 1,25-(OH)₂D Assay\nElevated Plasma 1,25-(OH)₂D Following Massive Dosing of Vitamin D₃ in Dairy Cattle\nVitamin D Metabolism in the Diabetic Rat\nThe Effect of Chronic Excess or Deficiency of Growth Hormone on Plasma 1,25-Dihydroxyvitamin D Levels in man\n25-Hydroxylation of Vitamin D in the Elderly\nIntestinal Absorption of Radiophosphate After Physiological Doses of 1,25-Dihydroxyvitamin D in Normals and Pathological Conditions\nCalcium Metabolism Following Proximal Gastric Vagotomy in Man\n25-Hydroxyvitamin D Metabolism in Nontropical Sprue\nCirculating Vitamin D Metabolites in A Hypoparathyroid Patient Resistent to Vitamin D\nThe Ability of 1a, 25-Dihydroxycholecalciferol to Alter the Fatty Acid Composition of Phosphoglycerides in Rat Intestinal Mucosa and Smooth Muscle\nVitamin D Dependent Clinical Disorders - Bone Disease : Clinical Aspects - Unanswered Questions in Renal Osteodystrophy - Problems of Vitamin D Nomenclature - Addendum\nAuthor Index\nSubject Index