دانلود کتاب Vitamin D hormone

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Content: Front Cover
Vitamin D Hormone
Copyright
Former Editors
Contents
Contributors
Preface
Chapter One: Vitamin D: Historical Overview
1. The Discovery of Vitamin D
2. The Discovery of the Physiological Functions of Vitamin D
3. The Discovery of the Hormonal Form of Vitamin D
4. The Isolation of the Final Active Form of Vitamin D
5. Discovery of the Vitamin D Endocrine System (Fig.5)
6. Other Metabolism of Vitamin D
7. Discovery of the Vitamin D Receptor
References
Chapter Two: Genomic Determinants of Vitamin D-Regulated Gene Expression
1. Introduction 2. Genome-Wide Analysis Reveals New Concepts in Vitamin D Action3. Novel Principles of Vitamin D Action
3.1. Modes of DNA Binding and Implications for the Regulatory Activity of the VDR
3.1.1. Ligand-Independent Function of the VDR in the Hair Cycle
3.1.2. Ligand-Independent Suppression of Gene Expression by the VDR
3.2. 1,25(OH)2D3 Regulates Transcription via Multiple Enhancers Located at Sites Distal to Gene Promoters
3.2.1. Defining Gene Regulation from Distal Sites
3.2.2. Confirming Enhancer Function at Target Genes 3.2.3. Application of the CRISPR/Cas9 Method to the Study of Gene Regulation4. The Influence of Cellular Differentiation on Vitamin D Activity
4.1. Differentiation Is Accompanied by Direct Alterations in the VDR Cistrome
4.2. The Impact of Osteoblast Differentiation on Master Regulatory Factor Distribution, Histone Modifying Activity, and R ...
4.3. Identification and Structure of the Osteoblast Enhancer Complex
5. VDR Modulates Histone Acetylation at Target Genes
6. Summary
Acknowledgments
References
Chapter Three: Inhibitors for the Vitamin D Receptor-Coregulator Interaction 1. Introduction1.1. VDR Coactivators
1.2. VDR Corepressors
2. Peptide-Based Inhibitors of the VDR-Coregulator Interaction
3. Small-Molecule Inhibitors of the VDR-Coregulator Interaction
4. VDR Antagonists or Allosteric Inhibition of the VDR-Coregulators Interaction
4.1. TEI-9647
4.2. ZK159222
4.3. ZK168281
4.4. ZK191784
4.5. Amide-Based VDR Antagonists
4.6. Adamantane-Based VDR Antagonists
4.7. Branched VDR Antagonists
5. Conclusion and Future Directions
Acknowledgments
References
Chapter Four: Structural Studies of Vitamin D Nuclear Receptor Ligand-Binding Properties 1. Introduction2. Crystal Structures of VDR LBD in Complex with 1,25(OH)2D3
2.1. Overall Organization of Human, Rat, and Zebrafish VDR-LBD Complexes
2.2. Activation Function-2
2.3. Recognition of Coactivator Peptide
2.4. VDR Ligand-Binding Pocket
3. Secosteroidal Derivatives of 1,25(OH)2D3
3.1. Superagonists of VDR
3.1.1. 20-Epi Derivatives
3.1.2. C2-Substituted Analogs
3.1.3. 14-Epi Analogs
3.2. Synthetic Compounds Expanding the VDR LBP
3.2.1. Gemini Analogs
3.2.2. 22-Alkyl Derivatives
3.2.3. Adamantyl-Containing Compounds
4. Synthetic Mimics of 1,25(OH)2D3